Folia Parasitologica, vol. 60 (2013), issue 5

Folia Parasitologica 60[5] 416-424 (2013) | 10.14411/fp.2013.044

Differences in some developmental features between Toxoplasma gondii-seropositive and seronegative school children

Hanna Mizgajska-Wiktor1, Wojciech Jarosz1, Izabela Andrzejewska2, Magdalena Krzykała3, Jarosław Janowski4, Maria Kozłowska5
1 Department of Biology and Environmental Protection, University School of Physical Education, Poznań, Poland;
2 Chair and Department of Biology and Medical Parasitology, University of Medical Sciences, Poznań, Poland;
3 Chair of Anthropology and Biometry, University School of Physical Education, Poznań, Poland;
4 Chair of Theory and Methodology of Sport, University School of Physical Education, Poznań, Poland;
5 Department of Mathematical and Statistical Methods, Poznań University of Life Sciences, Poznań, Poland

Abstract: Knowledge about the influence of latent toxoplasmosis on development and general biological condition of children is scant and thus the aim of the present study was to investigate these aspects in some detail. We compare school children in rural area seropositive and seronegative to the apicomplexan parasite Toxoplasma gondii (Nicolle et Manceaux, 1908) in terms of their developmental age, body mass and body height, physical fitness and end-of-term grades. Additionally, we evaluated the risk factors of infection with T. gondii such as the presence of cats in the household and eating raw meat products. With IFAT and ELISA tests, the prevalence of anti-Toxoplasma antibodies was 41% (190 children examined) and the rate of infection was higher in girls (44%) than in boys (36%). No significant differences were observed in morphological features and physical fitness of examined children. In girls the level of developmental age measured with electrophoretical mobility of nuclei method was significantly higher and school performance significantly lower for those infected with Toxoplasma than for uninfected; this finding was particularly intriguing. Only boys who ate raw meat products were more likely to be seropositive. The study provides some new information on gender differences in reaction to Toxoplasma infection.

Keywords: toxoplasmosis, developmental age, physical fitness, risk factors, children development

Received: January 5, 2013; Accepted: May 24, 2013; Published: November 27, 2013



This article contains supporting information (Fig. S1-S2) online at 2013-60-5-416.pdf



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References

  1. Brkic S., Gajski G., Bogavac M., Maric D., Turkulov V., Tomic S. 2010: [Seroprevalence of toxoplasmosis in Vojvodina]. Srp. Arh. Celok. Lek. 138: 333-336. (In Serbian.) Go to original source... Go to PubMed...
  2. Czapla Z., Cieslik J. 1998: The electrophoretic mobility of cell nuclei (EMN) index - relation to biological and physical properties of the cell. Anthropol. Rev. 61: 93-101
  3. Dubey J.P. 1998: Advances in the life cycle of Toxoplasma gondii. Int. J. Parasitol. 28: 1019-1024 Go to original source... Go to PubMed...
  4. Flegr J. 2010: Influence of latent toxoplasmosis on the phenotype of intermediate hosts. Folia Parasitol. 57: 81-87 Go to original source... Go to PubMed...
  5. Flegr J., Havlicek J., Kodym P., Maly M., Smahel Z. 2002: Increased risk of traffic accidents in subjects with latent toxoplasmosis: a retrospective case-control study. BMC Infect. Dis. 2: 11 Go to original source... Go to PubMed...
  6. Flegr J., Hruskova M., Hodny Z., Novotna M., Hanusova J. 2005: Body height, body mass index, waist-hip ratio, fluctuating asymmetry and second to fourth digit ratio in subjects with latent toxoplasmosis. Parasitology 130: 621-628 Go to original source... Go to PubMed...
  7. Flegr J., Kodym P., Tolarova V. 2000: Correlation of duration of latent Toxoplasma gondii infection with personality changes in women. Biol. Psychol. 53: 57-68 Go to original source... Go to PubMed...
  8. Flegr J., Preiss M., Klose J., Havlicek J., Vitakova M., Kodym P. 2003: Decreased level of psychobiological factor novelty seeking and lower intelligence in men latently infected with the protozoan parasite Toxoplasma gondii Dopamine, a missing link between schizophrenia and toxoplasmosis? Biol. Psychol. 63: 253-268 Go to original source... Go to PubMed...
  9. Flegr J., Zitkova S., Kodym P., Frynta D. 1996: Induction of changes in human behaviour by the parasitic protozoan Toxoplasma gondii. Parasitology 113: 49-54 Go to original source... Go to PubMed...
  10. Goldman M. 1957: Staining Toxoplasma gondii with fluorescein-labelled antibody. II. A new serologic test for antibodies to Toxoplasma based upon inhibition of specific staining. J. Exp. Med. 105: 557-573 Go to original source... Go to PubMed...
  11. Gutierrez J., Roldan C., Maroto M.C. 1996: Seroprevalence of human toxoplasmosis. Microbios 85: 73-75 Go to PubMed...
  12. Havlicek J., Gasova Z., Smith A.P., Zvara K., Flegr J. 2001: Decrease of psychomotor performance in subjects with latent "asymptomatic" toxoplasmosis. Parasitology 122: 515-520 Go to original source... Go to PubMed...
  13. Hay J., Aitken P.P., Hair D.M., Hutchison W.M., Graham D.I. 1984: The effect of congenital Toxoplasma infection on mouse activity and relative preference for exposed areas over a series of trials. Ann. Trop. Med. Parasitol. 78: 611-618 Go to original source... Go to PubMed...
  14. Huldt G., Lagercrantz R., Sheehe P.R. 1979: On the epidemiology of human toxoplasmosis in Scandinavia especially in children. Acta Paediatr. Scand. 68: 745-749 Go to original source... Go to PubMed...
  15. Hutchinson W.M., Bradley M., Cheyne W.M., Wells B.W., Hay J. 1980: Behavioural abnormalities in Toxoplasma-infected mice. Ann. Trop. Med. Parasitol. 74: 337-345 Go to original source... Go to PubMed...
  16. Jarosz W., Mizgajska-Wiktor H., Kirwan P., Konarski J., Rychlicki W., Wawrzyniak G. 2010: Developmental age, physical fitness and Toxocara seroprevalence amongst lower-secondary students living in rural areas contaminated with Toxocara eggs. Parasitology 137: 53-63 Go to original source... Go to PubMed...
  17. Jones J.L., Kruszon-Moran D., Won K., Wilson M., Schantz P.M. 2008: Toxoplasma gondii and Toxocara spp. co-infection. Am. J. Trop. Med. Hyg. 78: 35-39 Go to PubMed...
  18. Kim K., Weiss L.M. 2008: Toxoplasma: the next 100 years. Microbes Infect. 10: 978-984 Go to original source... Go to PubMed...
  19. Kolbekova P., Kourbatova E., Novotna M., Kodym P., Flegr J. 2007: New and old risk-factors for Toxoplasma gondii infection: prospective cross-sectional study among military personnel in the Czech Republic. Clin. Microbiol. Infect. 13: 1012-1017 Go to original source... Go to PubMed...
  20. Leogrande G. 1992: Studies on the epidemiology of child infections in the Bari area (south Italy). V. Epidemiology of Toxoplasma gondii infections. Microbiologica 15: 237-241 Go to PubMed...
  21. Mohan B., Dubey M.L., Malla N., Kumar R. 2002: Seroepidemiological study of toxoplasmosis in different sections of population of Union Territory of Chandigarh. J. Commun. Dis. 34: 15-22 Go to PubMed...
  22. Roberts C.W., Walker W., Alexander J. 2001: Sex-associated hormones and immunity to protozoan parasites. Clin. Microbiol. Rev. 14: 476-488 Go to original source... Go to PubMed...
  23. Robertson I.D., Irwin P.J., Lymbery A.J., Thompson R.C.A. 2000: The role of companion animals in the emergence of parasitic zoonoses. Int. J. Parasitol. 30: 1369-1377 Go to original source... Go to PubMed...
  24. Rodrigues I.M., Castro A.M., Gomes M.B., Amaral W.N., Avelino M.M. 2009: Congenital toxoplasmosis: evaluation of serological methods for the detection of anti-Toxoplasma gondii IgM and IgA antibodies. Mem. Inst. Oswaldo Cruz 104: 434-440 Go to original source... Go to PubMed...
  25. Shakhbazov V.G., Colupaeva T.V., Nabokov A.L. 1986: [New method for determining the biological age of humans.] Lab. Delo 7: 404-407. (In Russian.) Go to PubMed...
  26. Shakhbazov V.G., Grigoreva N.N., Colupaeva T.V. 1996: [A new cyto-biophysical index of biological age and the physiological state of the human body.] Fiziol. Cheloveka 22: 71-75. (In Russian.) Go to PubMed...
  27. Stinson S., Bogin B., Huss-Ashmore R., O'Rourke D. (Eds.) 2000: Human Biology: An Evolutionary and Biocultural Perspective. Wiley-Liss, New York, 656 pp
  28. Szewczyk-Kramska B. 1999: [Toxoplasmosis and toxocarosis in children from Wielkopolska]. Now. Lekarskie 68: 621-632. (In Polish.)
  29. Taylor M.R, Lennon B., Holland C.V., Cafferkey M. 1997: Community study of Toxoplasma antibodies in urban and rural schoolchildren aged 4 to 18 years. Arch. Dis. Child. 77: 406-409 Go to original source... Go to PubMed...
  30. Tenter A.M., Heckeroth A.R., Weiss L.M. 2000: Toxoplasma gondii: from animals to humans. Int. J. Parasitol. 30: 1217-1258 (with erratum in Int. J. Parasitol. 31 (2001): 217-220) Go to original source...
  31. Thomas D.R., Salmon R.L., Lewis G., Smith A.P. 2004: Toxoplasma and Coxiella infection and psychiatric morbidity: a retrospective cohort analysis. BMC Psychiatry 4: 32 Go to original source... Go to PubMed...
  32. Torrey E.F., Yolken R.H. 2003: Toxoplasma gondii and schizophrenia. Emerg. Infect. Dis. 9: 1375-1380 Go to original source... Go to PubMed...
  33. Wachowski E., Strzelczyk R., Osinski W. 1987: [Measurement of Motor Fitness in Individuals Practicing Sport: Results of Research]. Monografia AWF Poznan, No. 238, 153 pp. (In Polish.)
  34. Walker J., Nokes D.J., Jennings R. 1992: Longitudinal study of Toxoplasma seroprevalence in South Yorkshire. Epidemiol. Infect. 108: 99-106 Go to original source... Go to PubMed...
  35. Webster J.P., Brunton C.F., MacDonald D.W. 1994: Effect of Toxoplasma gondii upon neophobic behaviour in wild brown rats, Rattus norvegicus. Parasitology 109: 37-43 Go to original source... Go to PubMed...
  36. Wolanski N. 2006: [Biological Development of Human: Bases of Auxology, Gerontology and Health Promotion]. Seventh Edition. Wydawnictwo Naukowe PWN, Warszawa, 545 pp. (In Polish.)