Folia Parasitologica 49[4] 249-251 (2002) | DOI: 10.14411/fp.2002.046

Leptin and leptin receptors during malaria infection in mice

Magdalena Pulido-Mendez1, Juan De Sanctis2, Alexis Rodríguez-Acosta3
1 Experimental Medicine Institute, Faculty of Medicine, Universidad Central de Venezuela, University City, 1041, Caracas, Venezuela
2 Immunology Institute, Faculty of Medicine, Universidad Central de Venezuela, University City, 1041, Caracas, Venezuela
3 Section of Immunochemistry, Tropical Medicine Institute, Universidad Central de Venezuela, University City, 1041, Caracas, Venezuela

Leptin, which is involved in a range of physiological processes, could be an important factor in the pathogenesis of malaria. We found that levels of leptin in serum and urine in Plasmodium berghei-infected mice increased progressively after infection, reaching a maximum value on day 6 post-infection. Serum values were approximately five-fold higher in infected mice than in non-infected controls. A similar relation was found for values of leptin in urine. Soluble leptin receptor levels also increased significantly in serum, more or less in line with the leptin increase. Our work represents the first report of visibly augmented leptin and soluble leptin receptor secretion in malarial infection.

Keywords: leptin, Plasmodium berghei, malaria, soluble leptin receptor

Received: November 5, 2001; Accepted: May 24, 2002; Published: December 1, 2002  Show citation

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Pulido-Mendez, M., De Sanctis, J., & Rodríguez-Acosta, A. (2002). Leptin and leptin receptors during malaria infection in mice. Folia Parasitologica, 49(4), 249-251. doi: 10.14411/fp.2002.046
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