Folia Parasitologica 45[4] 257-260 (1998)

Sphingomyelin synthesis in helminths: a minireview

Ilia Bankov1, Anna Timanova1, John Barrett2
1 Institute of Experimental Pathology and Parasitology, Bulgarian Academy of Sciences, Acad.G.Bontchev Str., Bl. 25, 1113 Sofia, Bulgaria
2 Institute of Biological Sciences, The University of Wales, Aberystwyth, Ceredigion SY23 3DA, U.K.

Sphingolipids are a diverse and ubiquitous group of lipids. They are widely distributed in parasites and a number of novel forms have been described. Sphingolipid synthesis has been investigated in the malarial parasite, cestodes, digeneans and nematodes. Although there are differences in detail, the synthetic pathways involved are similar to those found in mammals.

Keywords: lipids, sphingomyelin, parasites, helminths, review

Received: September 25, 1997; Accepted: February 18, 1998; Published: December 1, 1998  Show citation

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Bankov, I., Timanova, A., & Barrett, J. (1998). Sphingomyelin synthesis in helminths: a minireview. Folia Parasitologica, 45(4), 257-260
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    References

    1. ANSORGE I., JECKEL D., WIELAND F., LINGELBACH K. 1995: Plasmodium falciparum-infected erythrocytes utilize a synthetic truncated ceramide precursor for synthesis and secretion of truncated sphingomyelin. Biochem. J. 308: 335-341 Go to original source... Go to PubMed...
    2. AREVALO J., SAZ H.J. 1991: Phospholipids and protein kinase C in acetyl-choline-dependent signal transduction in Ascaris suum. Mol. Biochem. Parasitol. 48: 151-161 Go to original source... Go to PubMed...
    3. BANKOV I., BARRETT J. 1985: Sphingomyelin synthesis in Hymenolepis diminuta (Cestoda). Mol. Biochem. Parasitol. 15: 341-347 Go to original source... Go to PubMed...
    4. BANKOV I., BARRETT J. 1990: Sphingomyelin synthesis in Fasciola hepatica. Int. J. Parasitol. 20: 581-585 Go to original source... Go to PubMed...
    5. BANKOV I., BARRETT J. 1993: Sphingomyelin synthesis in Ascaridia galli. Int. J. Parasitol. 23: 1083-1085 Go to original source... Go to PubMed...
    6. BARRETT J. 1983: Lipid metabolism. In: C. Arme and P.W. Pappas (Eds.), The Biology of the Eucestoda, Vol. 2. Academic Press, London, pp. 392-419
    7. BRICHON G., EL BABILI M., ZWINGELSTEIN G. 1996: Does sphingomyelin participate in signal transduction in gill cells of euryhaline crabs during salinity changes. Comp. Biochem. Physiol. 115B: 7-12 Go to original source...
    8. DRESSLER K.A., KAN C.C., KOLESNICK R.N. 1991: Sphingomyelin synthesis is involved in adherence during macrophage differentiation of HL-60 cells. J. Biol. Chem. 266: 11522-11527 Go to original source...
    9. ELMENDORF H.G., HALDAR K. 1993: Identification and localization of ERD2 in the malaria parasite Plasmodium falciparum; separation from sites of sphingomyelin synthesis and implications for organization of the Golgi. EMBO J. 12: 4763-4773 Go to original source... Go to PubMed...
    10. ELMENDORF H.G., HALDAR K. 1994: Plasmodium falciparum - export of Golgi sphingomyelin synthase into a tubovesicular network in the cytoplasm of mature erythrocytes. J. Biol. Chem. 124: 449-462 Go to original source... Go to PubMed...
    11. HALDAR K., UYETAKE L., GHORI N., ELMENDORF H.G., LI W.L. 1991: The accumulation and metabolism of a fluorescent ceramide derivative in Plasmodium falciparum-infected erythrocytes. Mol. Biochem. Parasitol. 49: 143-156 Go to original source... Go to PubMed...
    12. HRZENJAK T., EHRLICH I. 1975: Polar lipids of parasitic helminths. I. Polar lipids of Fasciola hepatica and Paramphistomum microbothrium. Veterinarski Arkhiv 45: 299-309
    13. JAYADEV S., LIU B., BIELAWSKA A.E., LEE J.Y., NAZAIRE F., YU M., PUSHKAREVA L.M., OBEID L.M., HANNUN Y.A. 1995: Role for ceramide in cell cycle arrest. J. Biol. Chem. 270: 2047-2052 Go to original source... Go to PubMed...
    14. JECKEL D., KARRENBAUER A., BIRK R., SCHMIDT R.R., WIELAND F. 1990: Sphingomyelin is synthesised in the cis Golgi. FEBS-Lett. 261: 155-157 Go to PubMed...
    15. KISHIMOTO Y. 1983: Sphingolipid formation. In: P.D. Bayer (Ed.), The Enzymes, Vol. 16, Third edition. Academic Press, New York, pp. 357-407 Go to original source...
    16. LAUER S.A., GHORI N., HALDAR K. 1995: Sphingolipid synthesis as a target for chemotherapy against malaria parasites. Proc. Natl. Acad. Sci. USA 92: 9181-9185 Go to original source... Go to PubMed...
    17. MAKAARU C.K., DAMIAN R.T., SMITH D.F., CUMMINGS R.D. 1992: The human blood fluke Schistosoma mansoni synthesizes a novel type of glycosphingolipid. J. Biol. Chem. 267: 2251-2257 Go to original source...
    18. MALONEY M.D., SEMPREVIVO L.H. 1991: Thin-layer and lipid column chromatographic analysis of the lipids of adult Onchocerca gibsoni. Parasitol. Res. 77: 294-300 Go to original source... Go to PubMed...
    19. MCMASTER C.R., MORASH S.C., BELL R.M. 1996: Phospholipid and cation activation of chimaeric choline/ethanolamine phosphotransferases. Biochem. J. 313: 729-735 Go to original source... Go to PubMed...
    20. MERRILL A.H., LINGRELL S., WANG E., NIKOLOVA KARAKASHIAN M., VALES T.R., VANCE D.E. 1995a: Sphingolipid biosynthesis de novo by rat hepatocytes in culture. Ceramide and sphingomyelin are associated with, but not required for very low density lipoprotein secretion. J. Biol. Chem. 270: 13834-13841 Go to original source... Go to PubMed...
    21. MERRILL A.H., SCHMELZ E.M., WANG E., SCHROEDER J., DILLEHAY D.L., RILIY R.T. 1995b: Role of dietary sphingolipids and inhibitors of sphingolipid metabolism in cancer and other diseases. J. Nutrit. 125: S1677-S1682
    22. NASHIMURA K., SUZUKI A., KUNO H. 1991: Sphingolipids of a cestode Metroliasthes coturnix. Biochim. Biophys. Acta, Lipids and Lipid Metab. 1086: 141-150 Go to PubMed...
    23. OBEID L.M., HANNUN Y.A. 1995: Ceramide: a stress signal and mediator of growth suppression and apoptosis. J. Cell. Biochem. 58: 191-198 Go to original source... Go to PubMed...
    24. OLDENBORG V., VAN VUGT F., VAN GOLDE L.M.G. 1975: Composition and metabolism of phospholipids of Fasciola hepatica, the common liver fluke. Biochim. Biophys. Acta 398: 101-110 Go to original source... Go to PubMed...
    25. PERSAT F., BOUHOURS J.F., MOJON M., PETAVY A.F. 1992: Glycosphingolipids with Galb1-6 Gal sequences in metacestodes of the parasite Echinococcus multilocularis. J. Biol. Chem. 267: 8764-8769 Go to original source...
    26. PERSAT F., BOUHOURS J.F., PETAVY A.F., MOJON M. 1995: Free ceramides of Echinococcus multilocularis metacestodes. Biochim. Biophys. Acta, Lipids and Lipid Metab. 1255: 280-284 Go to PubMed...
    27. PUSHKAREVA M., CHAO R., BIELAWSKA A., MERRILL A.H., CRANE H.M., LAGU B., LIOTTA D., HANNUN Y.A. 1995: Stereoselectivity of induction of the retinoblastoma gene product (pRb) dephosphorylation by D-erythro-sphingosine supports a role for pRb in growth suppression by sphingosine. Biochemistry 34: 1885-1892 Go to original source... Go to PubMed...
    28. SCHWEIZER A., CLAUSEN H., VAN MEER G., HAURI H.P. 1994: Localisation of O-glycan initiation, sphingomyelin synthesis, and glycosylceramide synthesis in Vero cells with respect to the endoplasmic reticulum-Golgi intermediate compartment. J. Biol. Chem. 269: 40354041 Go to original source...
    29. SCIDMORE M.A., FISCHER E.R., HACKSTADT T. 1996: Sphingolipids and glycoproteins are differentially trafficked to the Chlamydia trachomatis inclusion. J. Cell Biol. 134: 363-374 Go to original source... Go to PubMed...

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